Expectations of Chronic GVHD Treatment

EP: 1.Acute Versus Chronic Graft-Versus-Host Disease (GVHD)

EP: 2.Phases of Pathophysiology of Chronic GVHD

EP: 3.Monitoring Patients with GVHD

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EP: 4.Expectations of Chronic GVHD Treatment

EP: 5.Targeted Treatments for GVHD

EP: 6.Corticosteroids and Clinical Trial Design in Chronic GVHD

EP: 7.Switching to Second Line Treatment in Chronic GVHD

EP: 8.Ruxolitinib in Chronic GVHD

EP: 9.Ibrutinib in Chronic GVHD

EP: 10.Belumosudil for Treatment of Chronic GVHD

EP: 11.A GVHD Clinical Scenario

EP: 12.Third Line Treatment in Chronic GVHD

EP: 13.Emerging Agents in GVHD: Axatilimab

EP: 14.Future Landscape of Chronic GVHD

EP: 15.Quality of Life and Patient Reported Outcomes (PRO) in Chronic GVHD

EP: 16.Practical Advice for Management of Chronic GVHD

This is a video synopsis of a discussion involving Dr Yi-Bin Chen, Director of the Transplant and Cell Therapy Program at Massachusetts General Hospital and Professor of Medicine at Harvard Medical School; Dr Corey Cutler, Director of the Stem Cell Transplant Program at Dana-Farber Cancer Institute and Professor of Medicine at Harvard Medical School; Dr Mitchell Horwitz, Professor of Medicine and Director of the Adult Blood and Marrow Transplant Program at Duke University, and Dr Hannah Choe, Assistant Professor and Director of the Graft-versus-Host-Disease (GVHD) program at Ohio State University.

The panel delves into the intricacies of managing chronic GVHD, shedding light on the recent developments in treatments arising from pivotal clinical trials and new approvals, providing more therapeutic options for medical practitioners and improved accessibility for patients.

Dr Yi-Bin Chen engages Dr Mitchell Horwitz in a detailed exploration of the treatment approach when encountering chronic GVHD symptoms in a patient approximately 8 months post-transplant. Dr Horwitz emphasizes the reassurance provided to patients about the commonality of chronic GVHD occurrences and elucidates the inverse correlation between chronic GVHD emergence and disease relapse, offering a comforting perspective.

The discussion evolves to address the crucial aspect of managing patient expectations during chronic GVHD treatment. Dr Horwitz navigates this delicate terrain, highlighting the temporal nature of chronic GVHD therapy and the imperative need for a balanced approach to mitigate potential risks associated with treatments. Dr Hannah Choe discusses the evolving landscape of expectations and cautioning against prematurely discontinuing therapy, particularly for patients with advanced disease.

Throughout the conversation, the panel underscores the importance of clear communication with patients, providing reassurance about the common occurrence of chronic GVHD, managing realistic expectations concerning response timelines, and cautioning against premature discontinuation of therapies.

In this nuanced and expert-guided discussion, the panel ensures a thorough understanding and effective management of chronic GVHD, a complex and multifaceted medical condition. The insights shared contribute significantly to the evolving landscape of chronic GVHD treatment strategies, providing a valuable resource for healthcare professionals and patients alike.

Video synopsis is AI-generated and reviewed by OncLive® editorial staff.