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Opinion|Videos|July 18, 2024

Expert Insights on ZUMA-3 Data Updates: 4-Year Follow-up and Real World Data

Author(s)Elias Jabbour, MD, Evandro D. Bezerra, MD, Lori Muffly, MD

A medical expert elaborates on the therapeutic role of brexucabtagene autoleucel in the management of relapsed or refractory B-cell acute lymphoblastic leukemia.

Episodes in this series

5 KOLs are featured in this series.

EP. 1 Overview of CAR T-cell Therapies in R/R B-cell ALL

5 KOLs are featured in this series.

EP. 2 CAR T-cell Therapy: Mechanisms of Actions of Brexucabtagene Autoleucel and Obecabtagene Autoleucel

5 KOLs are featured in this series.

EP. 3 Considerations for Dosing and Lymphodepletion with CAR T-cell Therapy in R/R ALL

5 KOLs are featured in this series.

EP. 4 Expert Perspectives on CAR T-Cell Therapy Logistics: Collection to Treatment

5 KOLs are featured in this series.

EP. 5 Overview of Available Treatment Options in R/R B-cell ALL

5 KOLs are featured in this series.

EP. 6 Navigating CAR T-cell Therapy in R/R ALL: Expert Perspectives

5 KOLs are featured in this series.

EP. 7 Expert Insights on ZUMA-3 Data Updates: 4-Year Follow-up and Real World Data

5 KOLs are featured in this series.

EP. 8 Treatment Considerations and Patient Selection for CAR T-cell Therapy in R/R ALL

5 KOLs are featured in this series.

EP. 9 Expert Perspectives on Bridging Therapy Strategies Prior to CAR T-cell Therapy

5 KOLs are featured in this series.

EP. 10 Sequencing Strategies with CAR T-cell Therapy in Patients with or without Prior Blinatumomab Treatment

5 KOLs are featured in this series.

EP. 11 Translating Data Updates from FELIX and ZUMA-3 to the Clinical Practice Setting

5 KOLs are featured in this series.

EP. 12 Expert Perspectives on the Potential Impact of Obe-cel on the Treatment Landscape for R/R ALL

5 KOLs are featured in this series.

EP. 13 Treatment Approaches with Consolidation and Maintenance Post CAR T-cell Therapy

5 KOLs are featured in this series.

EP. 14 Future Perspectives on CAR T-cell Therapy in R/R B-cell ALL

5 KOLs are featured in this series.

EP. 15 Frequency, Correlation with Clinical Outcomes, and Risk Factors for Severe CRS and ICANS in CAR T-cell Therapy

5 KOLs are featured in this series.

EP. 16 Expert Perspectives in Monitoring and Management Strategies for CRS, ICANS, and Other Long-Term Toxicities Associated with CAR T-cell Therapy

5 KOLs are featured in this series.

EP. 17 Logistical and Access Challenges with CAR T-cell Therapy in R/R ALL

5 KOLs are featured in this series.

EP. 18 Strategies and Resources for Overcoming Barriers to CAR T-Cell Therapy

5 KOLs are featured in this series.

EP. 19 Role of Multidisciplinary Team & Logistics of CAR T-cell Therapy Administration in the Inpatient or Outpatient Setting

5 KOLs are featured in this series.

EP. 20 Key Takeaways and Clinical Pearls in the Treatment of R/R ALL

Video content above is prompted by the following:

Please review the role of brexu-cel in R/R B-cell ALL.
Please review ZUMA-3 ASCO 2024 abstract 4-yr updates.
- What are pertinent patient characteristics of this trial?
- What were some key points?
- What noteworthy efficacy or safety outcomes were demonstrated?
- What are the clinical implications from these recent long-term data updates?
How have real-world outcomes and your personal clinical experience compared to the ZUMA-3 results?

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