Expert Perspectives on Differentiating Signs and Symptoms in AL Amyloidosis Diagnosis

Opinion
Video

Vaishali Sanchorawala, MD, examines the signs and symptoms linked to AL amyloidosis, underscoring that distinctive symptoms may not manifest in patients until later stages of the disease, potentially causing delays in diagnosis.

This is a video synopsis/summary of a Peer Exchange involving Heather Landau, MD; Vaishali Sanchorawala, MD; and Jeffrey Zonder, MD.

Panelists discuss diagnostic challenges in light chain (AL) amyloidosis and underscore the rarity of the disease, necessitating a high clinical suspicion for red flag symptoms like fatigue and peripheral edema. Specific signs, including periorbital ecchymosis and tongue enlargement, are highlighted. They emphasize the rarity-related misdiagnoses, where common conditions are often considered first, delaying amyloidosis identification. They express concern for patients with nonspecific symptoms being overlooked, emphasizing the rarity challenge in diagnosis. The discussion stresses the need for heightened awareness among health care professionals to promptly detect AL amyloidosis and prevent misdiagnoses, crucial for effective management of this uncommon disease.

Video synopsis is AI-generated and reviewed by OncLive® editorial staff.

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