Exploring Therapeutic Avenues in HER2+ Breast Cancer

EP: 1.Evolving HER2+ Breast Cancer Care: Neo-Adjuvant Strategies and Treatment Goals

EP: 2.Neoadjuvant Approaches in HER2+ Breast Cancer

EP: 3.HER2+ Breast Cancer: Anthracycline Considerations

EP: 4.Subcutaneous HER2+ Breast Cancer Treatment Trends

EP: 5.Adjuvant Strategies in HER2+ Brest Cancer: Timing and Tailoring

EP: 6.Evolving Strategies in Adjuvant HER2+ Breast Cancer

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EP: 7.Exploring Therapeutic Avenues in HER2+ Breast Cancer

EP: 8.Metastatic HER2+ Breast Cancer: Current Strategies and Ongoing Trials

EP: 9.Navigating Second-Line Choices in HER2+ Breast Cancer

EP: 10.Decoding HER2+ Breast Cancer: Challenges in Brain Metastases

EP: 11.Navigating HER2+ Brain Metastases: Emerging Insights

EP: 12.HER2+ Breast Cancer Treatment Dynamics and Challenges

EP: 13.Navigating Treatment Challenges in HER2+ Breast Cancer

EP: 14.Insights and Challenges in Advancing HER2+ Breast Cancer Care

This is a video synopsis/summary of a Peer Exchange involving Joyce O’Shaughnessy, MD; Priyanka Sharma, MD; Claudine Isaacs, MD; Heather McArthur, MD; and Hope S. Rugo, MD, FASCO.

O’Shaughnessy and Rugo discuss the potential of neratinib in addressing residual disease after T-DM1 treatment in patients with HER2-positive breast cancer. The external study showed positive results, especially in patients who are estrogen-receptor positive, highlighting the need for additional therapies to prevent metastasis. O’Shaughnessy acknowledges the ongoing CompassHER2 RD trial’s aim to reduce the risk of brain metastasis by combining T-DM1 (trastuzumab emtansine) with tucatinib. Isaacs stresses the importance of enrolling patients in trials targeting brain metastases, aiming for better standards of care. The discussion emphasizes the optimization of endocrine therapy for HER2-positive patients and ongoing efforts to improve treatment strategies in both adjuvant and metastatic settings.

Video synopsis is AI-generated and reviewed by OncLive^® editorial staff.