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The FDA has granted an approval to brentuximab vedotin (Adcetris) in combination with adriamycin, vinblastine, and dacarbazine as a frontline treatment for patients with advanced classical Hodgkin lymphoma.
The decision is based on findings from the phase III ECHELON-1 trial, in which brentuximab vedotin plus AVD compared with standard ABVD, known as AVD plus bleomycin, demonstrated superior progression-free survival.
In the study, the brentuximab vedotin regimen reduced the risk of progression, death, or initiation of new therapy by 23% versus ABVD. The 2-year modified PFS rate was 82.1% with brentuximab vedotin compared with 77.25% for standard chemotherapy.
The FDA granted a breakthrough therapy designation for brentuximab vedotin in combination with chemotherapy for frontline advanced classical Hodgkin lymphoma in October 2017.
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