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Opinion|Videos|March 30, 2026

Frontline Decision-Making in EGFR-Mutant NSCLC

Author(s)Heather Wakelee, MD, Helena A. Yu, MD

Heather Wakelee, MD, and Helena Yu, MD, discuss how they approach patient selection for osimertinib monotherapy vs combination therapy in 2026.

Episodes in this series

EP. 1 Frontline Decision-Making in EGFR-Mutant NSCLC

EP. 1 Frontline Decision-Making in EGFR-Mutant NSCLC

EP. 2 Interpreting FLAURA2 for Sequencing Strategies in in EGFR-Mutant NSCLC

EP. 2 Interpreting FLAURA2 for Sequencing Strategies in in EGFR-Mutant NSCLC

EP. 3 The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

EP. 3 The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

EP. 4 Impact of Co-Mutations on Treatment Strategies in in EGFR-Mutant NSCLC

EP. 4 Impact of Co-Mutations on Treatment Strategies in in EGFR-Mutant NSCLC

EP. 5 Integrating ADCs Into the Treatment Paradigm in in EGFR-Mutant NSCLC

EP. 5 Integrating ADCs Into the Treatment Paradigm in in EGFR-Mutant NSCLC

EP. 6 Building a Sequencing Roadmap at Diagnosis in in EGFR-Mutant NSCLC

EP. 6 Building a Sequencing Roadmap at Diagnosis in in EGFR-Mutant NSCLC

EP. 7 Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

EP. 7 Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

Heather Wakelee, MD, and Helena Yu, MD, explore how frontline treatment decisions are evolving in EGFR-mutant advanced non–small cell lung cancer. They discuss how clinical factors such as central nervous system involvement, disease burden, and patient comorbidities inform the choice between osimertinib (Tagrisso) monotherapy and combination approaches. The conversation also highlights the importance of long-term sequencing considerations, anticipated subsequent therapies, and the role of guidelines such as those from the National Comprehensive Cancer Network in shaping individualized treatment strategies.

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