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Opinion|Videos|April 7, 2026

The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

Author(s)Heather Wakelee, MD, Helena A. Yu, MD

Heather Wakelee, MD, and Helena Yu, MD, discuss when chemotherapy rechallenge may be appropriate in EGFR-mutant NSCLC.

Episodes in this series

EP. 1 Frontline Decision-Making in EGFR-Mutant NSCLC

EP. 1 Frontline Decision-Making in EGFR-Mutant NSCLC

EP. 2 Interpreting FLAURA2 for Sequencing Strategies in in EGFR-Mutant NSCLC

EP. 2 Interpreting FLAURA2 for Sequencing Strategies in in EGFR-Mutant NSCLC

EP. 3 The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

EP. 3 The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

EP. 4 Impact of Co-Mutations on Treatment Strategies in in EGFR-Mutant NSCLC

EP. 4 Impact of Co-Mutations on Treatment Strategies in in EGFR-Mutant NSCLC

EP. 5 Integrating ADCs Into the Treatment Paradigm in in EGFR-Mutant NSCLC

EP. 5 Integrating ADCs Into the Treatment Paradigm in in EGFR-Mutant NSCLC

EP. 6 Building a Sequencing Roadmap at Diagnosis in in EGFR-Mutant NSCLC

EP. 6 Building a Sequencing Roadmap at Diagnosis in in EGFR-Mutant NSCLC

EP. 7 Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

EP. 7 Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

Heather Wakelee, MD, and Helena Yu, MD, evaluate the clinical role of chemotherapy rechallenge in the treatment landscape. They discuss which patients may derive meaningful benefit, including those with a durable initial response, and how treatment-free interval factors into decision-making. The conversation also compares rechallenge strategies with alternative options such as antibody-drug conjugates and clinical trials, and whether chemotherapy rechallenge is underutilized or appropriately reserved.

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