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Opinion|Videos|April 21, 2026

Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

Author(s)Heather Wakelee, MD, Helena A. Yu, MD

Heather Wakelee, MD, and Helena Yu, MD, discuss emerging biomarkers and key evidence gaps in EGFR-mutant NSCLC.

Episodes in this series

EP. 1 Frontline Decision-Making in EGFR-Mutant NSCLC

EP. 1 Frontline Decision-Making in EGFR-Mutant NSCLC

EP. 2 Interpreting FLAURA2 for Sequencing Strategies in in EGFR-Mutant NSCLC

EP. 2 Interpreting FLAURA2 for Sequencing Strategies in in EGFR-Mutant NSCLC

EP. 3 The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

EP. 3 The Role of Chemotherapy Rechallenge in in EGFR-Mutant NSCLC

EP. 4 Impact of Co-Mutations on Treatment Strategies in in EGFR-Mutant NSCLC

EP. 4 Impact of Co-Mutations on Treatment Strategies in in EGFR-Mutant NSCLC

EP. 5 Integrating ADCs Into the Treatment Paradigm in in EGFR-Mutant NSCLC

EP. 5 Integrating ADCs Into the Treatment Paradigm in in EGFR-Mutant NSCLC

EP. 6 Building a Sequencing Roadmap at Diagnosis in in EGFR-Mutant NSCLC

EP. 6 Building a Sequencing Roadmap at Diagnosis in in EGFR-Mutant NSCLC

EP. 7 Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

EP. 7 Future Directions and Unmet Needs in in EGFR-Mutant NSCLC

Heather Wakelee, MD, and Helena Yu, MD, highlight ongoing challenges and future directions in the field. They discuss the potential for biomarkers beyond EGFR and TP53 to further refine treatment decisions and identify novel therapeutic targets under investigation. The conversation concludes with a focus on the types of data that could most meaningfully impact clinical practice, including studies that better define optimal sequencing and guide treatment de-escalation.

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