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Opinion|Videos|March 26, 2026

How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

Author(s)Christine M. Lovly, MD, PhD, Matthew Lee, MD

Christine Lovly, MD, PhD, and Matthew Lee, MD, discuss how data help shape first-line treatment decisions in EGFR-mutated non–small cell lung cancer.

Episodes in this series

EP. 1 How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

EP. 1 How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

EP. 2 Navigating Second-Line Treatment Decisions in EGFR+ NSCLC

EP. 2 Navigating Second-Line Treatment Decisions in EGFR+ NSCLC

EP. 3 Sequencing Considerations and Planning in EGFR+ NSCLC

EP. 3 Sequencing Considerations and Planning in EGFR+ NSCLC

EP. 4 Implications of the FDA Approval of Subcutaneous Amivantamab in EGFR+ NSCLC

EP. 4 Implications of the FDA Approval of Subcutaneous Amivantamab in EGFR+ NSCLC

EP. 5 Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

EP. 5 Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

EP. 6 How Ongoing Research Could Reshape EGFR+ NSCLC Management

EP. 6 How Ongoing Research Could Reshape EGFR+ NSCLC Management

Christine Lovly, MD, PhD, and Matthew Lee, MD, examine how risk–benefit considerations inform frontline treatment selection in EGFR-mutated non–small cell lung cancer. Lovly highlights the role of efficacy, toxicity, and patient-specific factors when choosing between monotherapy and combination approaches such as osimertinib (Tagrisso)-based regimens or amivantamab-vmjw (Rybrevant) plus lazertinib (Lazcluze). Lee emphasizes how clinical trial data and value frameworks can help contextualize these decisions in routine practice.

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