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Opinion|Videos|April 8, 2026

Sequencing Considerations and Planning in EGFR+ NSCLC

Author(s)Christine M. Lovly, MD, PhD, Matthew Lee, MD

Christine Lovly, MD, PhD, and Matthew Lee, MD, discuss factors that drive treatment and sequencing planning in EGFR-mutated non–small cell lung cancer.

Episodes in this series

EP. 1 How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

EP. 1 How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

EP. 2 Navigating Second-Line Treatment Decisions in EGFR+ NSCLC

EP. 2 Navigating Second-Line Treatment Decisions in EGFR+ NSCLC

EP. 3 Sequencing Considerations and Planning in EGFR+ NSCLC

EP. 3 Sequencing Considerations and Planning in EGFR+ NSCLC

EP. 4 Implications of the FDA Approval of Subcutaneous Amivantamab in EGFR+ NSCLC

EP. 4 Implications of the FDA Approval of Subcutaneous Amivantamab in EGFR+ NSCLC

EP. 5 Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

EP. 5 Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

EP. 6 How Ongoing Research Could Reshape EGFR+ NSCLC Management

EP. 6 How Ongoing Research Could Reshape EGFR+ NSCLC Management

Christine Lovly, MD, PhD, and Matthew Lee, MD, explore key considerations for treatment sequencing across the EGFR-mutated non–small cell lung cancer continuum. Lovly explains how frontline choices can influence downstream options, particularly in the context of resistance pathways and CNS involvement. Lee adds that a proactive, longitudinal treatment strategy is critical to optimizing outcomes as more therapies become available.

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