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Opinion|Videos|April 22, 2026

Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

Author(s)Christine M. Lovly, MD, PhD, Matthew Lee, MD

Christine Lovly, MD, PhD, and Matthew Lee, MD, detail implementation and safety considerations for subcutaneous amivantamab in EGFR-mutated NSCLC.

Episodes in this series

EP. 1 How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

EP. 1 How Risk Benefit Profiles Aid in Treatment Selection in EGFR+ NSCLC

EP. 2 Navigating Second-Line Treatment Decisions in EGFR+ NSCLC

EP. 2 Navigating Second-Line Treatment Decisions in EGFR+ NSCLC

EP. 3 Sequencing Considerations and Planning in EGFR+ NSCLC

EP. 3 Sequencing Considerations and Planning in EGFR+ NSCLC

EP. 4 Implications of the FDA Approval of Subcutaneous Amivantamab in EGFR+ NSCLC

EP. 4 Implications of the FDA Approval of Subcutaneous Amivantamab in EGFR+ NSCLC

EP. 5 Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

EP. 5 Implementing Subcutaneous Amivantamab in Clinical Practice for EGFR+ NSCLC

EP. 6 How Ongoing Research Could Reshape EGFR+ NSCLC Management

EP. 6 How Ongoing Research Could Reshape EGFR+ NSCLC Management

Christine Lovly, MD, PhD, and Matthew Lee, MD, review key safety data for amivantamab and hyaluronidase-lpuj (Rybrevant Faspro; subcutaneous amivantamab) and how this formulation can be implemented into clinical practice for EGFR-mutated non–small cell lung cancer. Lovly highlights the improved tolerability profile observed with the subcutaneous formulation, including a lower incidence of infusion-related reactions and more streamlined administration compared with intravenous dosing. Lee discusses real-world integration considerations, including patient selection, toxicity monitoring, and how this formulation may enhance treatment adherence and clinic efficiency.

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