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Opinion|Videos|January 21, 2025

Key Differences in T-Cell Response Therapy vs CAR T Therapy

A panelist discusses how T-cell receptor (TCR) therapy offers potential advantages over chimeric antigen receptor (CAR) T therapy in solid tumors due to its ability to recognize intracellular antigens through human leukocyte antigen (HLA) presentation and its generally better safety profile with lower cytokine release syndrome rates, though TCR therapy faces its own challenges, including HLA restriction and potential cross-reactivity risks.

Episodes in this series

2 expert is featured in this series.

EP. 1 Brief Overview of Synovial Sarcoma: What It Is, Clinical Presentation and Diagnosis

2 expert is featured in this series.

EP. 2 Addressing Unmet Needs in Synovial Sarcoma and Recent FDA Approval of Afami-cel

2 expert is featured in this series.

EP. 3 SPEARHEAD-1: Overview of Study Design, Key Efficacy, and Safety

2 expert is featured in this series.

EP. 4 Afami-cel Approval and Its Potential Influence on the Adoption of TCR Therapies

2 expert is featured in this series.

EP. 5 Key Differences in T-Cell Response Therapy vs CAR T Therapy

2 expert is featured in this series.

EP. 6 Optimal Timing for Introducing Afami-Cel Therapy in the Treatment Journey

2 expert is featured in this series.

EP. 7 Sequencing Strategies of Afami-Cel With Chemotherapy and Targeted Therapies

2 expert is featured in this series.

EP. 8 Addressing Potential Barriers to the Adoption of Afami-Cel Therapy

2 expert is featured in this series.

EP. 9 Best Practices for HLA and MAGE-A4 Testing

2 expert is featured in this series.

EP. 10 Diagnositc Feasibility: Liquid Biopsy vs Tissue Biopsy for Diagnostic Testing

2 expert is featured in this series.

EP. 11 Approaches to First-Line Treatment for Synovial Sarcoma

2 expert is featured in this series.

EP. 12 Potential Impact of Afami-Cel Therapy on the Standard of Care for R/R Cases

2 expert is featured in this series.

EP. 13 Comparing Postinfusion Challenges in TCR Therapy and Standard-of-Care Regimens

2 expert is featured in this series.

EP. 14 Logistical Considerations for Delivering TCR Therapy to Patients

2 expert is featured in this series.

EP. 15 Comparing Afami-Cel Outcomes With Chemotherapy and Other Treatment Options

2 expert is featured in this series.

EP. 16 Future Perspectives on TCR Therapies for Sarcomas and Other Solid Tumors

Video content above is prompted by the following:

What are the key differences between TCR technology vs CAR T technology in this space? (Focusing on the differences in safety profiles seen in TCR and the ability to work well in solid tumors where CAR T has struggled)

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