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Opinion|Videos|January 7, 2025

SPEARHEAD-1: Overview of Study Design, Key Efficacy, and Safety

Panelists discuss how afamitresgene autoleucel (afami-cel) demonstrated meaningful clinical activity in SPEARHEAD-1, with manageable cytokine release syndrome as the main safety concern.

Episodes in this series

2 expert is featured in this series.

EP. 1 Brief Overview of Synovial Sarcoma: What It Is, Clinical Presentation and Diagnosis

2 expert is featured in this series.

EP. 2 Addressing Unmet Needs in Synovial Sarcoma and Recent FDA Approval of Afami-cel

2 expert is featured in this series.

EP. 3 SPEARHEAD-1: Overview of Study Design, Key Efficacy, and Safety

2 expert is featured in this series.

EP. 4 Afami-cel Approval and Its Potential Influence on the Adoption of TCR Therapies

2 expert is featured in this series.

EP. 5 Key Differences in T-Cell Response Therapy vs CAR T Therapy

2 expert is featured in this series.

EP. 6 Optimal Timing for Introducing Afami-Cel Therapy in the Treatment Journey

2 expert is featured in this series.

EP. 7 Sequencing Strategies of Afami-Cel With Chemotherapy and Targeted Therapies

2 expert is featured in this series.

EP. 8 Addressing Potential Barriers to the Adoption of Afami-Cel Therapy

2 expert is featured in this series.

EP. 9 Best Practices for HLA and MAGE-A4 Testing

2 expert is featured in this series.

EP. 10 Diagnositc Feasibility: Liquid Biopsy vs Tissue Biopsy for Diagnostic Testing

2 expert is featured in this series.

EP. 11 Approaches to First-Line Treatment for Synovial Sarcoma

2 expert is featured in this series.

EP. 12 Potential Impact of Afami-Cel Therapy on the Standard of Care for R/R Cases

2 expert is featured in this series.

EP. 13 Comparing Postinfusion Challenges in TCR Therapy and Standard-of-Care Regimens

2 expert is featured in this series.

EP. 14 Logistical Considerations for Delivering TCR Therapy to Patients

2 expert is featured in this series.

EP. 15 Comparing Afami-Cel Outcomes With Chemotherapy and Other Treatment Options

2 expert is featured in this series.

EP. 16 Future Perspectives on TCR Therapies for Sarcomas and Other Solid Tumors

Video content above is prompted by the following:

Briefly review the pivotal SPEARHEAD-1 trial that led to afami-cel’s approval.
Please review study design, key efficacy and safety (Tine et al, CTOS2022).
Please explain the role of targeting MAGE-A4.

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