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Opinion|Videos|June 4, 2025

Looking to the Future: Emerging Therapeutic Approaches in HER2+ Breast Cancer

Author(s)Erika P. Hamilton, MD, Heather McArthur, MD, MPH, Kelly E. McCann, MD, PhD

Panelists discuss how emerging developments in HER2-positive (HER2+) breast cancer treatment, including novel antibody-drug conjugates, bispecific antibodies, and cytotoxic-sparing regimens for hormone receptor+ (HR+)/HER2+ disease, are creating exciting new options for patients.

Episodes in this series

3 experts are featured in this series.

EP. 1 Clinical Scenario I: 52-year-old Woman With Recurrent Metastatic HER2+ Breast Cancer

3 experts are featured in this series.

EP. 2 Clinical Insights Into Treatment Approach for Metastatic HER+ mBC Patient Case

3 experts are featured in this series.

EP. 3 Expert Perspectives on Navigating Treatment-Related Adverse Events With T-DXd

3 experts are featured in this series.

EP. 4 Managing Brain Metastases in HER2+ Breast Cancer: Second-Line Treatment Decisions

3 experts are featured in this series.

EP. 5 Forty-Seven-Year-Old Woman With Recurrent HER2+ Breast Cancer and Brain Metastases

3 experts are featured in this series.

EP. 6 Clinical Insights on the Next Treatment Approach for Metastatic HER2+ Breast Cancer with Brain Metastasis

3 experts are featured in this series.

EP. 7 Navigating Third-Line Treatment Options in HER2+ Breast Cancer: ADC or TKI

3 experts are featured in this series.

EP. 8 Tucatinib Combinations in HER2+ Breast Cancer: HER2CLIMB-02 and HER2CLIMB-05

3 experts are featured in this series.

EP. 9 Balancing Efficacy and Tolerability: Expert Insights Into Tucatinib Triplet Therapy for HER2+ Breast Cancer

3 experts are featured in this series.

EP. 10 Clinical Insights Into Managing Heavily Pretreated HER2+ Metastatic Breast Cancer

3 experts are featured in this series.

EP. 11 Looking to the Future: Emerging Therapeutic Approaches in HER2+ Breast Cancer

Clinical Brief: Future Directions in HER2+ Breast Cancer

Key Themes:

Novel Therapeutic Approaches: Development of new antibody-drug conjugates, bispecific antibodies, and HER3-targeted agents
Cytotoxic-Sparing Regimens: Potential for chemotherapy-free approaches for HR+, HER2+ disease
Treatment Individualization: Increasing ability to tailor treatment based on disease characteristics and patient preferences

Key Points for Physicians:

HER2 gene amplification provides a stable therapeutic target compared with more heterogeneous cancers
For HR+/HER2+ disease, combinations of endocrine therapy with HER2-targeted agents may offer quality-of-life benefits
The growing treatment armamentarium allows for more personalized approaches considering efficacy, toxicity, and quality of life

Notable Insights:

The transformation of HER2+ breast cancer from a poor prognosis to having multiple effective treatment options is remarkable
Innovations in brain metastases management have been particularly transformative
The evolution of treatment options allows physicians to consider both treatment efficacy and impact on quality of life

Clinical Significance:

The treatment landscape for HER2+ breast cancer continues to evolve rapidly, with emerging therapies and strategies focused on improving efficacy and maintaining quality of life. This represents a paradigm shift in the management of what was once considered a highly aggressive disease with limited options.

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