
Opinion|Videos|January 8, 2025
Managing RET Inhibitor Treatment-Related Adverse Events
Author(s)Heather A. Wakelee, MD, FASCO, Jacob Sands, MD
Panelists discuss the common adverse effects for patients receiving selpercatinib or pralsetinib, strategies for managing these effects, and whether differences in the safety profiles of these drugs influence treatment choices for RET fusion–positive non–small cell lung cancer.
Advertisement
Episodes in this series

- Dr Wakelee to Dr Sands: What adverse effects are common for patients receiving selpercatinib or pralsetinib?
- How do you manage these adverse effects?
- Are there any differences in safety profiles of these drugs that influence your treatment choice?
LIBRETTO-431 Trial ARROW Trial ARROW Trial Update Annals of Oncology, 2022 - Dr Wakelee to Dr Sands: In what situations do you consider dose modifications of RET inhibitors? How often do you find this necessary in your practice?
Advertisement
Related to this article

The FDA has approved pirtobrutinib for the treatment of adult patients with previously untreated CLL or SLL harboring no known 17p deletion.

By finding a way to attack the most important human oncogene, KRAS, the UCSF chemical biologist launched a new era in cancer treatment.

TRE-515 earned fast track status in combination with KRAS inhibitors for G12C-mutated NSCLC after anti–PD-(L)1 therapy and platinum-based chemotherapy.

An NDA for zipalertinib in EGFR exon 20 insertion–positive NSCLC is being supported by phase 3 REZILIENT3 data.

Did you catch all of this week's top oncology news? Test your knowledge with OncLive's Weekly News Quiz.

Aglatimagene besadenovec plus EBRT was linked to a 41% lower risk of prostate cancer recurrence or death, alongside durable immune activity.

In case you missed any, read a recap of the episodes of OncLive On Air that aired in September 2026.
Advertisement
Advertisement
Trending on OncLive
1
FDA Approves Pirtobrutinib for Previously Untreated CLL/SLL
2
Oral Azacitidine and Cedazuridine Meets Primary Pharmacokinetic End Point in MDS and CMML
3
Revisit Every OncLive On Air Episode From September 2026
4
UTRxMYCN M1-14 Nets FDA Dual Designations in Soft Tissue Sarcoma
5


