Video

Dr. Mesa on Ruxolitinib in Chronic Myeloid Leukemia

Ruben A. Mesa, MD, Professor of Medicine, Division of Hematology & Medical Oncology, Mayo Clinic, discusses the mechanism of action of ruxolitinib in chronic myeloid leukemia.

Ruben A. Mesa, MD, Professor of Medicine, Division of Hematology & Medical Oncology, Mayo Clinic, discusses the mechanism of action of ruxolitinib and interest in JAK1/2 inhibition in patients with chronic myeloid leukemia (CML).

Ruxolitinib is an inhibitor of JAK1 and JAK2 but it is not specific to these mutations, unlike the TKIs currently available to treat CML, which are targeted to BCR-ABL. This attribute makes the agent a potentially unique treatment in CML.

Treatment with ruxolitinib seems to impact JAK2 V617F allele burden. Overall, Mesa says, V617F is a point mutation and currently there is not a sythesized molecule that is specific to this mutation. However, Mesa notes, researchers believe the upregulation of JAK2, whether through the V617F mutation or another mutation, is a key target and its inhibition provides benefit. As a result, there are several trials looking at combinations that target pathways upstream or downstream of JAK2, including treatment with PI3K and mTOR inhibitors.

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Latest CME

View All
Community Oncology Connections™: Community Oncologists’ Role in Selecting Optimal Oral SERD Treatment for HR+/HER2– Breast Cancer | Arizona
Video

Community Oncology Connections™: Community Oncologists’ Role in Selecting Optimal Oral SERD Treatment for HR+/HER2– Breast Cancer | Arizona

May 13th 2025 - Jun 18th 2025

online-activity
16th Annual International Symposium on Ovarian Cancer and Other Gynecological Malignancies™
Video

16th Annual International Symposium on Ovarian Cancer and Other Gynecological Malignancies™

May 9th 2025 - Jun 14th 2025

online-activity
Proactive Adverse Event Management for HER2+ BTC Treatments
Video

Proactive Adverse Event Management for HER2+ BTC Treatments

May 8th 2025 - May 9th 2026

online-activity