|Videos|August 13, 2020

Metastatic Triple-Negative Breast Cancer Ongoing Trials

Author(s)Sara A. Hurvitz, MD, David Geffen School of Medicine, Aditya Bardia, MD, MPH, FASCO, Claudine Isaacs, MD, Lombardi Comprehensive Cancer Center

A discussion on various ongoing clinical trials regarding the management of metastatic triple-negative breast cancer.

Data from the following clinical trials are discussed:

KEYNOTE-355: Randomized, double-blind, phase III study of pembrolizumab + chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer. (Cortes, ASCO 2020 Abstract 1000)
TBCRC 048: A phase II study of olaparib in metastatic breast cancer patients with germline or somatic mutations in DNA damage response pathway genes (Olaparib Expanded). (Tung, ASCO 2020 Abstract 1002)
Results of a phase II randomized trial of cisplatin +/- veliparib in metastatic triple-negative breast cancer and/or germline BRCA-associated breast cancer (SWOG S1416). (Sharma, ASCO 2020 Abstract 1001)

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Metastatic Triple-Negative Breast Cancer Ongoing Trials

Data from the following clinical trials are discussed:

KEYNOTE-355: Randomized, double-blind, phase III study of pembrolizumab + chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer. (Cortes, ASCO 2020 Abstract 1000)

TBCRC 048: A phase II study of olaparib in metastatic breast cancer patients with germline or somatic mutations in DNA damage response pathway genes (Olaparib Expanded). (Tung, ASCO 2020 Abstract 1002)

Results of a phase II randomized trial of cisplatin +/- veliparib in metastatic triple-negative breast cancer and/or germline BRCA-associated breast cancer (SWOG S1416). (Sharma, ASCO 2020 Abstract 1001)

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