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Opinion|Videos|January 26, 2024

Objectives, Clinical Endpoints, and Safety Profile of the Phase 2 ZUMA-3 Clinical Trial

Author(s)Gregory W. Roloff, MD, Jae Park, MD, Bijal D. Shah, MD

Dr. Bijal and colleagues discuss the objectives, clinical outcomes, and safety profile of the Phase 2 ZUMA 3 clinical trial, which evaluated treatment of adult patients with relapsed or refractory, B-precursor, acute lymphoblastic leukemia with the anti-CD-19/anti-CD20 bispecific CAR-T cell therapy, KTE-X19 (brexucabtagene autoleucel).

Episodes in this series

EP. 1 Faculty Introductions

EP. 1 Faculty Introductions

EP. 2 Objectives of the 2023 ASH Insights Program on CAR-T Cell Therapy for Adult B Cell ALL

EP. 2 Objectives of the 2023 ASH Insights Program on CAR-T Cell Therapy for Adult B Cell ALL

EP. 3 Overview of the Current State of CART19 Therapy for Adult Patients With R/R ALL

EP. 3 Overview of the Current State of CART19 Therapy for Adult Patients With R/R ALL

EP. 4 Objectives, Clinical Endpoints, and Safety Profile of the Phase 2 ZUMA-3 Clinical Trial

EP. 5 Progression-Free Survival, Overall Survival, and the Prognostic Significance of Negative Minimal Residual Disease

EP. 5 Progression-Free Survival, Overall Survival, and the Prognostic Significance of Negative Minimal Residual Disease

EP. 6 Standardizing and Optimizing Bridging Strategies Prior to CAR-T Infusion

EP. 6 Standardizing and Optimizing Bridging Strategies Prior to CAR-T Infusion

EP. 7 Outcomes of the Retrospective, Multicenter ROCCA Analysis (Real-World Outcomes Collaborative of CAR-T in Adult ALL)

EP. 7 Outcomes of the Retrospective, Multicenter ROCCA Analysis (Real-World Outcomes Collaborative of CAR-T in Adult ALL)

EP. 8 Influences on Treatment Response and Survival in Recipients of Brexucabtagene Autoleucel Therapy

EP. 8 Influences on Treatment Response and Survival in Recipients of Brexucabtagene Autoleucel Therapy

$EP. 9 Optimal Sequencing of Therapy for Previously Treated Patients With Relapsed or Refractory ALL$

EP. 9 Optimal Sequencing of Therapy for Previously Treated Patients With Relapsed or Refractory ALL

EP. 10 Emerging Therapies for the Older Patient With Acute Lymphoblastic Leukemia

EP. 10 Emerging Therapies for the Older Patient With Acute Lymphoblastic Leukemia

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