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Opinion|Videos|December 1, 2025

Ongoing Research to Watch in Advanced Gastric/GEJ Cancer

Author(s)Yelena Y. Janjigian, MD, Zev A. Wainberg, MD

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, discuss ongoing trials that could help refine the gastric/GEJ cancer treatment paradigm.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Standards and Unmet needs in Advanced Gastric/GEJ Cancer

2 experts are featured in this series.

EP. 2 EDGE-Gastric Trial: Breaking Down Data for Domvanalimab/Zimberelimab Plus Chemo in First-Line Gastric/GEJ/Esophageal Adenocarcinoma

2 experts are featured in this series.

EP. 3 Detailing the Ongoing Phase 3 STAR-221 Trial of Domvanalimab/Zimberelimab Plus FOLFOX in First-Line Gastric/GEJ/Esophageal Adenocarcinoma

2 experts are featured in this series.

EP. 4 Where Domvanalimab/Zimberelimab/Chemo Could Fit in the Advanced Gastric/GEJ/Esophageal Adenocarcinoma Paradigm

2 experts are featured in this series.

EP. 5 Ongoing Research to Watch in Advanced Gastric/GEJ Cancer

2 experts are featured in this series.

EP. 6 Other Key Data in Gastric/GEJ Cancer Presented at ESMO 2025

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, outline major ongoing research efforts aimed at improving outcomes for patients with advanced gastric and GEJ cancers. They emphasize the importance of continued evaluation of immunotherapy combinations, biomarker-directed approaches, and next-generation targeted therapies. Janjigian and Wainberg also highlight broader areas of investigation in gastrointestinal oncology that could shape future treatment paradigms.

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