Opinion|Videos|November 24, 2025
Where Domvanalimab/Zimberelimab/Chemo Could Fit in the Advanced Gastric/GEJ/Esophageal Adenocarcinoma Paradigm
Author(s)Yelena Y. Janjigian, MD, Zev A. Wainberg, MD
Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, discuss the potential clinical implications of the investigation of domvanalimab plus zimberelimab and FOLFOX in gastric/GEJ/esophageal adenocarcinoma.
Advertisement
Episodes in this series
Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, explore how positive STAR-221 results could transform first-line management for advanced gastric, GEJ, and esophageal adenocarcinoma. They examine how the domvanalimab plus zimberelimab and FOLFOX regimen might fit within the current therapeutic landscape and potentially broaden available immunotherapy options. Janjigian and Wainberg consider whether this approach could emerge as a new standard of care and what factors would influence real-world adoption.
Advertisement
Related to this article
The decision removes the triple-class–refractory requirement and allows melflufen use after at least 2 prior lines of therapy.
Anktiva plus BCG improved efficacy vs BCG alone in cohort A of QUILT-2.005 in BCG-naive NMIBC.
The FDA set a June 25, 2027, target action date for gedatolisib plus fulvestrant in PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer.
Read a refresh of hematologic cancer FDA news from October 2026, including the approval of a noncovalent BTK inhibitor in untreated CLL/SLL.
SER-155 showed early promise in reducing bloodstream infections in patients undergoing donor stem cell transplants for blood cancers.
Advances in endocrine therapy, immunotherapy, and ADCs frame unresolved breast cancer treatment questions ahead of BTG 2026.
During a recent OncLive Peer Exchange, multiple myeloma experts discussed how BCMA-directed therapies can be selected and sequenced.
Trine Jakobi Nøttrup, MD, PhD, discusses data for the hTERT-directed vaccine UV1 in BRCA wild-type recurrent ovarian cancer/
Advertisement
Advertisement
Trending on OncLive
1
Cesalatamig Monotherapy Shows Dose-Dependent Activity in PD-(L)1 Inhibitor–Experienced NSCLC
2
Dr Moser on Outcomes for WTX-124 ± Pembrolizumab in Advanced Immune-Sensitive Solid Tumors
3
Dr Banks on the Feasibility of Lifileucel in Select Metastatic Sarcomas
4
BCMA-Directed Bispecifics and ADCs Broaden Treatment Sequencing Options in R/R Myeloma
5