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Opinion|Videos|November 24, 2025

Where Domvanalimab/Zimberelimab/Chemo Could Fit in the Advanced Gastric/GEJ/Esophageal Adenocarcinoma Paradigm

Author(s)Yelena Y. Janjigian, MD, Zev A. Wainberg, MD

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, discuss the potential clinical implications of the investigation of domvanalimab plus zimberelimab and FOLFOX in gastric/GEJ/esophageal adenocarcinoma.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Standards and Unmet needs in Advanced Gastric/GEJ Cancer

2 experts are featured in this series.

EP. 2 EDGE-Gastric Trial: Breaking Down Data for Domvanalimab/Zimberelimab Plus Chemo in First-Line Gastric/GEJ/Esophageal Adenocarcinoma

2 experts are featured in this series.

EP. 3 Detailing the Ongoing Phase 3 STAR-221 Trial of Domvanalimab/Zimberelimab Plus FOLFOX in First-Line Gastric/GEJ/Esophageal Adenocarcinoma

2 experts are featured in this series.

EP. 4 Where Domvanalimab/Zimberelimab/Chemo Could Fit in the Advanced Gastric/GEJ/Esophageal Adenocarcinoma Paradigm

2 experts are featured in this series.

EP. 5 Ongoing Research to Watch in Advanced Gastric/GEJ Cancer

2 experts are featured in this series.

EP. 6 Other Key Data in Gastric/GEJ Cancer Presented at ESMO 2025

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, explore how positive STAR-221 results could transform first-line management for advanced gastric, GEJ, and esophageal adenocarcinoma. They examine how the domvanalimab plus zimberelimab and FOLFOX regimen might fit within the current therapeutic landscape and potentially broaden available immunotherapy options. Janjigian and Wainberg consider whether this approach could emerge as a new standard of care and what factors would influence real-world adoption.

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