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Opinion|Videos|November 17, 2025

Current Standards and Unmet needs in Advanced Gastric/GEJ Cancer

Author(s)Yelena Y. Janjigian, MD, Zev A. Wainberg, MD

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, discuss current treatment standards in advanced gastric/GEJ cancer.

Episodes in this series

2 experts are featured in this series.

EP. 1 Current Standards and Unmet needs in Advanced Gastric/GEJ Cancer

2 experts are featured in this series.

EP. 2 EDGE-Gastric Trial: Breaking Down Data for Domvanalimab/Zimberelimab Plus Chemo in First-Line Gastric/GEJ/Esophageal Adenocarcinoma

2 experts are featured in this series.

EP. 3 Detailing the Ongoing Phase 3 STAR-221 Trial of Domvanalimab/Zimberelimab Plus FOLFOX in First-Line Gastric/GEJ/Esophageal Adenocarcinoma

2 experts are featured in this series.

EP. 4 Where Domvanalimab/Zimberelimab/Chemo Could Fit in the Advanced Gastric/GEJ/Esophageal Adenocarcinoma Paradigm

2 experts are featured in this series.

EP. 5 Ongoing Research to Watch in Advanced Gastric/GEJ Cancer

2 experts are featured in this series.

EP. 6 Other Key Data in Gastric/GEJ Cancer Presented at ESMO 2025

Yelena Y. Janjigian, MD, and Zev A. Wainberg, MD, review the current frontline standards of care for advanced gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma, emphasizing how modern immunotherapy-based regimens have reshaped treatment expectations. They highlight key gaps in care, including heterogeneous patient biology, limited durability of response, and the need for more precise biomarker-driven strategies. Janjigian and Wainberg also discuss patient- and disease-specific prognostic factors that influence outcomes and inform individualized treatment planning.

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