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Idalid Franco, MD, MPH, discusses the integration of immunotherapy, molecular biomarkers, and risk factors for recurrence into the endometrial cancer paradigm. 

Navigating the Intersection of Radiation Therapy and Immunotherapy in Endometrial Cancer

R. Lor Randall, MD, FACS, discusses the changing field of orthopedic oncology and gives his takeaways from the American Academy of Orthopedic Surgeons Meeting.

As Orthopedic Oncology Evolves, Caring for the Clinician Must Be a Priority  

Belumosudil elicited sustained responses and generated no new safety signals in patients with chronic graft-vs-host disease.

Belumosudil Produces Long-Term Responses Without New Safety Concerns in cGVHD

Itacitinib prophylaxis showed signals for reducing CRS and ICANS following treatment with axicabtagene ciloleucel in patients with B-cell lymphoma. 

Prophylactic Itacitinib May Safely Mitigate CRS Following Axi-Cel Administration in Lymphoma

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Kenneth C. Anderson, MD, discusses the recent ODAC decisions for ide-cel and cilta-cel, highlighting clinical trial data supporting the indications.

ODAC Decisions Confirm Benefit of Ide-Cel and Cilta-Cel in Earlier Line R/R Myeloma Therapy

Topline findings with the next-generation ColoAlert® test demonstrated 92% sensitivity and 90% specificity rates for colorectal cancer detection. 

Next-Generation ColoAlert Screening Test Shows High Sensitivity, Specificity for CRC and Adenoma Detection

Vebreltinib has received approval from China’s NMPA in pretreated IDH-mutant, PTPRZ1-MET fusion–positive astrocytoma or glioblastoma.

Vebreltinib Receives NMPA Approval in China for MET Fusion+ Glioma

Caroline Seymour is your initial point of contact for the 

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CTX-009 plus paclitaxel has received FDA fast track designation for pretreated metastatic or locally advanced biliary tract cancer.

FDA Grants Fast Track Designation to CTX-009 Plus Paclitaxel for Pretreated Biliary Tract Cancer

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Post-Conference Perspectives: Managing R/R B-ALL with CAR T-Cell Therapy

Videos

Jae Park, MD, reviews key data in the management of relapsed/refractory B-cell acute lymphoblastic leukemia (R/R B-ALL) recently presented at the ASCO 2023 Annual Meeting.

Jae Park, MD, explains how B-cell acute lymphoblastic leukemia is diagnosed, and the testing done for detection of genetic abnormalities, which impacts treatment and prognosis.

Signs and Symptoms of B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Dr Jae Park details the treatment options for relapsed/refractory B-cell acute lymphoblastic leukemia, including blinatumomab, inotuzumab ozogamicin, and CAR T-cell therapy, with the treatment choice dependent on patient factors like comorbidities, disease burden, and transplant status.

Available Treatment Options for Patients With Relapsed/Refractory (R/R) B-ALL

Jae Park, MD, reviews updated data from the ZUMA-3 trial on the use of the CAR T-cell therapy brexucabtagene autoleucel (brexu-cel) for relapsed/refractory B-cell acute lymphoblastic leukemia, noting high remission rates, management of side effects like cytokine release syndrome, and post-CAR-T consolidation, including transplant.

R/R B-ALL: Key Efficacy Outcomes From the Updated Analysis of the ZUMA-3 Trial

Dr Jae Park discusses managing cytokine release syndrome and the neurotoxicity side effects of CAR T-cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia through medications, disease burden reduction, and earlier intervention to prevent severe toxicities.

R/R B-ALL: Key Safety Outcomes From the Updated Analysis of the ZUMA-3 Trial

Jae Park, MD, explains how real-world CAR T-cell therapy data in patients with relapsed/refractory B-cell acute lymphoblastic leukemia shows high response rates but emphasizes the ongoing need for optimizing toxicity management, with trends toward earlier treatment and cell collection.

Outcomes Data Following Brexucabtagene Autoleucel Therapy in Patients With R/R B-ALL

Dr Jae Park shares his experience with using brexucabtagene autoleucel for patients with relapsed/refractory B-cell acute lymphoblastic leukemia in clinical practice since its FDA approval in October 2021.

An Oncologist’s Experience With Treating R/R B-ALL With Brexucabtagene Autoleucel in Clinical Practice

Jae Park, MD, wraps up his discussion by highlighting exciting investigational agents on the horizon for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia.

The Future of R/R B-ALL Treatment

Outcomes Data Following Brexucabtagene Autoleucel Therapy in Patients With R/R B-ALL

EP: 1.Signs and Symptoms of B-Cell Acute Lymphoblastic Leukemia (B-ALL)

EP: 2.Available Treatment Options for Patients With Relapsed/Refractory (R/R) B-ALL

EP: 3.R/R B-ALL: Key Efficacy Outcomes From the Updated Analysis of the ZUMA-3 Trial

EP: 4.R/R B-ALL: Key Safety Outcomes From the Updated Analysis of the ZUMA-3 Trial

EP: 5.Outcomes Data Following Brexucabtagene Autoleucel Therapy in Patients With R/R B-ALL

EP: 6.An Oncologist’s Experience With Treating R/R B-ALL With Brexucabtagene Autoleucel in Clinical Practice

EP: 7.The Future of R/R B-ALL Treatment

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