Commentary|Videos|June 14, 2024

Poised Potential With Zenocutuzumab in NRG1+ Pancreatic Cancer

Author(s)E. Gabriela Chiorean, MD, FASCO

E. Gabriela Chiorean, MD, of Fred Hutch Cancer Center, discusses the recent clinical data with zenocutuzumab in patients with NRG1 fusion–positive pancreatic cancer and the impact the approval of this agent could have on the landscape.

Episodes in this series

D. Ross Camidge, MD, PhD

EP. 1 Prevalence of NRG1 Fusions in Lung Cancer

D. Ross Camidge, MD, PhD

EP. 2 Differences Between DNA and RNA Testing for NRG1

D. Ross Camidge, MD, PhD

EP. 3 Standard Treatments for NRG1 Fusion+ NSCLC

D. Ross Camidge, MD, PhD

EP. 4 Ongoing Research Efforts Targeting NRG1 in Lung Cancer

D. Ross Camidge, MD, PhD

EP. 5 Efficacy With NRG1-Directed Agents in NSCLC

E. Gabriela Chiorean, MD

EP. 6 Prognosis, Rarity of NRG1+ Pancreatic Cancer

E. Gabriela Chiorean, MD

EP. 7 Choosing RNA Over DNA Testing for NRG1 Fusions in Pancreatic Cancer

E. Gabriela Chiorean, MD

EP. 8 Standard Treatment Regimens for NRG1+ Pancreatic Cancer

E. Gabriela Chiorean, MD

EP. 9 Poised Potential With Zenocutuzumab in NRG1+ Pancreatic Cancer

Haley M. Hill, PA-C, discusses current approaches and treatment challenges in NRG1-positive non–small cell lung cancer and pancreatic cancer.

EP. 10 Current Approaches and Treatment Challenges in NRG1+ NSCLC and Pancreatic Cancer

Haley M. Hill, PA-C, discusses DNA vs RNA sequencing for genetic testing in non–small cell lung cancer and pancreatic cancer.

EP. 11 DNA vs RNA Sequencing in NSCLC and Pancreatic Cancer

Haley M. Hill, PA-C, discusses how physician assistants aid in treatment planning for NRG1-positive non–small cell lung cancer and pancreatic cancer.

EP. 12 A Physician Assistant's Perspective: Treatment Planning in NRG1+ NSCLC and Pancreatic Cancer

Haley M. Hill, PA-C, discusses preliminary data for zenocutuzumab in NRG1 fusion–positive non–small cell lung cancer and pancreatic cancer.

EP. 13 The Potential Role for Zenocutuzumab in NRG1+ NSCLC and Pancreatic Cancer

Haley M. Hill, PA-C, discusses the role of multidisciplinary management in NRG1-positive non–small cell lung cancer and pancreatic cancer.

EP. 14 Using a Multidisciplinary Treatment Approach in NRG1+ NSCLC and Pancreatic Cancer

Mary B. Beasley, MD, discusses the prevalence of NRG1 fusions in non–small cell lung cancer and pancreatic cancer.

EP. 15 Harnessing the Ability to Target NRG1 Fusions in NSCLC, Pancreatic Cancer

Mary B. Beasley, MD, discusses the role of RNA and other testing considerations for detecting NRG1 and other fusions in solid tumors.

EP. 16 The Role of RNA in Detecting NRG1 and Other Fusions in Solid Tumors

Mary B. Beasley, MD, discusses the role of pathologists in molecular testing in non–small cell lung cancer and pancreatic cancer.

EP. 17 The Pathologist’s Role in Molecular Testing in NSCLC, Pancreatic Cancer

Mary B. Beasley, MD, discusses the multidisciplinary management of NRG1 fusion–positive non–small cell lung cancer and pancreatic cancer.

EP. 18 Using a Multidisciplinary Approach in NRG1+ NSCLC, Pancreatic Cancer

Mary B. Beasley, MD, discusses molecular testing challenges in non–small cell lung cancer and pancreatic cancer.

EP. 19 Overcoming Challenges With Molecular Testing in NSCLC, Other Solid Tumors

NRG1 Fusions in Lung Cancer | Image Credit: © catalin – stock.adobe.com

EP. 20 NRG1 Fusions Emerge as New Target of Interest in Lung, Pancreatic Cancers

Newsletter

Stay up to date on the most recent and practice-changing oncology data

Related to this article

The top 5 OncLive TV videos of the week cover insights in essential thrombocythemia, CML, pancreatic cancer, myelofibrosis, and chronic neutropenia.

September 6th, 2026

Five Under 5: Top Oncology Videos for the Week of 8/31/26

The top 5 OncLive TV videos of the week cover insights in essential thrombocythemia, CML, pancreatic cancer, myelofibrosis, and chronic neutropenia.

The FDA approved daraxonrasib for pancreatic cancer, cleared zanidatamab-based regimens for HER2-positive gastric cancer, and more.

August 29th, 2026

The OncFive: Top Oncology Articles for the Week of 8/23

The FDA approved daraxonrasib for pancreatic cancer, cleared zanidatamab-based regimens for HER2-positive gastric cancer, and more.

Trending on OncLive

Revumenib Plus Chemo Yields High Response and MRD-Negativity Rates in Newly Diagnosed NPM1+ or KMT2A+ AML

Ofirnoflast Elicits Durable Transfusion Independence, Hematologic Improvement in Lower-Risk MDS

ACTIVE Regimen Elicits High Response Rates in R/R NPM1-Mutated AML

Dr Gangat on Phase 2 Efficacy and Safety Data for DISC-3405 in Polycythemia Vera

DISC-3405 Reduces Phlebotomy Events and Controls Hematocrit in Polycythemia Vera