Rugo Summarizes Developments With Ribociclib and ADCs in HR-Positive Breast Cancer

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Dr Rugo discusses overall survival in the TROPiCS-02 trial, post-progression treatments after ribociclib and endocrine therapy in the MONALEESA-2, MONALEESA-3, and MONALEESA-7 studies, and what the AMALEE trial indicates about optimal doses of ribociclib in hormone receptor–positive breast cancer.

Welcome to OncLive On Air®! I’m your host today, Ashling Wahner.

OncLive On Air® is a podcast from OncLive®, which provides oncology professionals with the resources and information they need to provide the best patient care. In both digital and print formats, OncLive® covers every angle of oncology practice, from new technology to treatment advances to important regulatory decisions.

In today’s episode, sponsored by Novartis, we had the pleasure of speaking with Hope S. Rugo, MD, FASCO, on updates in hormone receptor (HR)–positive breast cancer presented at the 2022 San Antonio Breast Cancer Symposium. Dr Rugo is a professor of medicine in the Division of Hematology and Oncology and the director of Breast Oncology and Clinical Trials Education at the University of California San Francisco Helen Diller Family Comprehensive Cancer Center.

In our exclusive interview, Dr Rugo discussed the findings from the second interim analysis of overall survival in the phase 3 TROPiCS-02 trial (NCT03901339), the implications of post-progression treatments after ribociclib (Kisqali) and endocrine therapy in the phase 3 MONALEESA-2 (NCT01958021), MONALEESA-3 (NCT02422615), and MONALEESA-7 (NCT02278120) studies, and what the phase 2 AMALEE trial (NCT03822468) indicates about optimal starting doses of first-line ribociclib in the HR-positive population.

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