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|Videos|February 7, 2022

SABCS 2021 Updates in CDK4/6 Inhibitors in Breast Cancer

Author(s)Sara A. Hurvitz, MD, Aditya Bardia, MD, MPH, FASCO, Patrick Neven, MD, PhD

Sara A. Hurvitz, MD; Aditya Bardia, MD, MPH; Patrick Neven, MD, PhD; and Kevin Kalinsky MD, MS, discuss SABCS 2021 updates on the use of CDK4/6 inhibitors in HR+/HER2 breast cancer.

Episodes in this series

EP. 1 Coming Soon: THE TALK: Breast Cancer, A Review of Data from the SABCS 2021 Virtual Meeting

EP. 1 Coming Soon: THE TALK: Breast Cancer, A Review of Data from the SABCS 2021 Virtual Meeting

EP. 2 SABCS 2021 Updates in ER+ Breast Cancer

EP. 2 SABCS 2021 Updates in ER+ Breast Cancer

EP. 3 SABCS 2021 Updates in CDK4/6 Inhibitors in Breast Cancer

EP. 3 SABCS 2021 Updates in CDK4/6 Inhibitors in Breast Cancer

EP. 4 SABCS 2021 Updates in Key Clinical Trials for Breast Cancer

EP. 4 SABCS 2021 Updates in Key Clinical Trials for Breast Cancer

Data from the following clinical trials are discussed:

P1-18-16: First-line aromatase inhibitor + palbociclib with randomized switch to fulvestrant [Faslodex] + palbociclib upon detection of circulating ESR1 mutation in HR+/HER2 metastatic breast cancer patients: Global safety results of PADA-1, a UCBG-GINECO phase 3 trial
PD2-05: Genomic profiling of PAM50-based intrinsic subtypes in HR+/HER2 advanced breast cancer across the MONALEESA studies
PD13-03: Ribociclib [Kisqali], everolimus, exemestane [Aromasin] triplet therapy in HR+/HER2 advanced breast cancer after progression on a CDK4/6 inhibitor: Final efficacy, safety, and biomarker results from TRINITI-1
PD02-04: Molecular plasticity of luminal A breast cancer and response to CDK4/6 inhibition: The biomarker program of the PENELOPE-B trial investigating post-neoadjuvant palbociclib

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