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Opinion|Videos|April 13, 2026

Sequencing Strategies After Frontline Intensification in EGFR-Mutant NSCLC

Author(s)Jonathan Riess, MD, MS, UC Davis Comprehensive Cancer Center, Nicolas Villanueva, MD

Jonathan Riess, MD, MS, and Nicholas Villanueva, MD, discuss treatment sequencing following progression on intensified regimens.

Episodes in this series

Experts featured in this series.

EP. 1 The Evolution of Frontline Therapy in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 2 Interpreting Overall Survival Data With Combination Strategies in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 3 Rethinking High-Risk EGFR-Mutant NSCLC

Experts featured in this series.

EP. 4 Integrating ctDNA Into Frontline Decision-Making in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 5 Sequencing Strategies After Frontline Intensification in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 6 The Emerging Role of ADCs in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 7 Future Directions: Toward Personalized EGFR Therapy in NSCLC

Jonathan Riess, MD, MS, and Nicholas Villanueva, MD, explore how prior exposure to chemotherapy influences second-line treatment decisions. They emphasize the importance of repeat biopsy, both tissue and liquid, to identify resistance mechanisms, including small cell transformation. The discussion also highlights how clinicians balance molecular findings with clinical tempo when selecting subsequent therapies.

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