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Opinion|Videos|April 13, 2026

The Emerging Role of ADCs in EGFR-Mutant NSCLC

Author(s)Jonathan Riess, MD, MS, UC Davis Comprehensive Cancer Center, Nicolas Villanueva, MD

Jonathan Riess, MD, MS, and Nicholas Villanueva, MD, discuss how antibody-drug conjugates are shaping treatment strategies after progression.

Episodes in this series

Experts featured in this series.

EP. 1 The Evolution of Frontline Therapy in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 2 Interpreting Overall Survival Data With Combination Strategies in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 3 Rethinking High-Risk EGFR-Mutant NSCLC

Experts featured in this series.

EP. 4 Integrating ctDNA Into Frontline Decision-Making in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 5 Sequencing Strategies After Frontline Intensification in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 6 The Emerging Role of ADCs in EGFR-Mutant NSCLC

Experts featured in this series.

EP. 7 Future Directions: Toward Personalized EGFR Therapy in NSCLC

Jonathan Riess, MD, MS, and Nicholas Villanueva, MD, examine the growing role of antibody-drug conjugates (ADCs) in the treatment landscape. They discuss how ADCs offer activity across heterogeneous resistance mechanisms and may serve as a bridge when targeted options are limited. The conversation also explores how prior therapies, including earlier-line intensification, may influence ADC effectiveness and sequencing decisions.

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