Opinion|Videos|February 9, 2026

The Role of Tumor Burden on Treatment Selection in EGFR-Mutated NSCLC

High tumor burden lung cancer demands fast action: start chemo while awaiting biomarkers, then add osimertinib for rapid symptom relief.

Narjust Florez, MD, explores how baseline tumor burden may influence therapeutic decision-making in EGFR-mutated non–small cell lung cancer (NSCLC). Florez discusses associations between disease volume, symptom burden, and urgency of response when considering systemic therapy options. She highlights how tumor burden can help frame risk–benefit discussions, particularly when balancing rapid disease control against potential toxicity.


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