Opinion|Videos|February 9, 2026

Time Toxicity and Treatment Selection in EGFR-Mutated NSCLC

High tumor burden lung cancer demands fast action: start chemo while awaiting biomarkers, then add osimertinib for quicker symptom relief.

Narjust Florez, MD, reviews retrospective data evaluating time toxicity associated with first-line treatments in EGFR-mutated non–small cell lung cancer. Florez discusses how time spent receiving care, including clinic visits and treatment-related monitoring, represents an underrecognized dimension of treatment burden. She emphasizes incorporating time toxicity into shared decision-making to better align therapy choice with patient quality-of-life priorities.


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