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Addressing De-Escalation of Treatment in HER2+ Breast Cancer

Angelica Welch
Published: Thursday, Nov 15, 2018

Priya Rastogi, MD

Priya Rastogi, MD

Data from the NSABP B-52, PERSEPHONE, and APT trials have called into question the optimal duration of treatment for patients with HER2-positive breast cancer.

The ongoing ATEMPT trial (NCT01853748) is building on what was demonstrated in the APT trial, Rastogi added. This trial is comparing ado-trastuzumab emtansine (T-DM1; Kadcyla) with paclitaxel plus trastuzumab. This phase II trial is active, but recruitment has closed.


  1. Rimawi MF, Cecchini RS, Rastogi P, et al. A phase III trial evaluating pCR in patients with HR+, HER2-positive breast cancer treated with neoadjuvant docetaxel, carboplatin, trastuzumab, and pertuzumab (TCHP) +/- estrogen deprivation: NRG Oncology/NSABP B-52. In: Proceedings from the 2016 San Antonio Breast Cancer Symposium; December 6-10, 2016; San Antonio, Texas. Abstract S3-06. doi: 10.1158/1538-7445.SABCS16-S3-06.
  2. Earl HM, Hiller L, Vallier A-L, et al. PERSEPHONE: 6 versus 12 months (m) of adjuvant trastuzumab in patients (pts) with HER2 positive (+) early breast cancer (EBC): Randomised phase 3 non-inferiority trial with definitive 4-year (yr) disease-free survival (DFS) results. J Clin Oncol. 2017;36(suppl; abstr 506).
  3. Tolaney SM, Barry WT, Guo H, et al. Seven-year (yr) followup of adjuvant paclitaxel (T) and trastuzumab (H) (APT trial) for node-negative, HER2-positive breast cancer (BC). J Clin Oncol. 2017;35(suppl 15):511. doi: 10.1200/JCO.2017.35.15_suppl.511.

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