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Apalutamide Approval Paves Way for Further Advances in Nonmetastatic CRPC

Caroline Seymour
Published: Wednesday, Mar 07, 2018

Alan H. Bryce, MD

Alan H. Bryce, MD
The space of nonmetastatic castration-resistant prostate cancer (CRPC) is beginning to evolve with recent advances highlighted by the FDA-approval of apalutamide (Erleada).

The FDA based its decision on findings from the phase III SPARTAN trial, in which the median metastasis-free survival (MFS) was 40.5 months in the apalutamide arm versus 16.2 months in the placebo arm (HR, 0.28; 95% CI, 0.23-0.35; P <.0001).1

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