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Avelumab Falls Short in Phase III Gastric Cancer Trial

Jason M. Broderick @jasoncology
Published: Tuesday, Nov 28, 2017

Chris Boshoff, MD, PhD
Chris Boshoff, MD, PhD
Avelumab (Bavencio) did not improve overall survival (OS) compared with chemotherapy in previously treated patients with gastric or gastroesophageal junction (GEJ) adenocarcinoma, according to findings from the phase III JAVELIN Gastric 300 trial.

Avelumab currently has FDA approved indications for urothelial carcinoma and Merkel cell carcinoma.
Chung HC, Arkenau H-T, Wyrwicz L, et al. Safety, PD-L1 expression, and clinical activity of avelumab (MSB0010718C), an anti-PD-L1 antibody, in patients with advanced gastric or gastroesophageal junction cancer. J Clin Oncol. 2016;34 (suppl 4S; abstr 167).

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