Jason M. Broderick

Articles

Atezolizumab Plus Cabozantinib Shows Meaningful Clinical Activity in mCRPC, Including High-Risk Subsets

September 19th 2021

The phase 1b COSMIC-021 trial showed clinically meaningful activity with cabozantinib plus atezolizumab in patients with locally advanced or metastatic castration-resistant prostate cancer who have been previously treated, including patients with high-risk features.

CDK Inhibition May Overcome Mechanisms of Olaparib Resistance in Prostate Cancer

September 15th 2021

By studying olaparib-sensitive and -resistant cell lines, researchers were able to gather insights regarding PARP inhibitor treatment and resistance mechanisms, including the use of CDK inhibition as a potential means of overcoming PARP inhibitor resistance in prostate cancer.

177Lu-PSMA-617 Plus Standard of Care Improves OS in mCRPC

June 3rd 2021

177Lu-PSMA-617, a targeted radioligand therapy, plus standard of care induced approximately a 40% reduction in the risk of death vs SOC alone in men with progressive PSMA-positive metastatic castration-resistant prostate cancer.

FDA Grants DKN-01 Orphan Drug Status for Gastric/GEJ Cancer

June 12th 2020

The FDA has granted an Orphan Drug designation to DKN-01 for the treatment of patients with gastric cancer or gastroesophageal junction cancer.

FDA Grants Berubicin Orphan Drug Status for Brain Cancer

June 11th 2020

The FDA has granted an orphan drug designation to berubicin for the treatment of patients with malignant gliomas.

FDA Approves Nivolumab for Esophageal Cancer

June 11th 2020

The FDA has approved nivolumab for the treatment of patients with unresectable advanced, recurrent or metastatic esophageal squamous cell carcinoma.

Pembrolizumab Combo Falls Short in Phase 3 Frontline Urothelial Carcinoma Trial

June 10th 2020

Adding pembrolizumab to chemotherapy did not lead to a statistically significant improvement in overall survival or progression-free survival in patients with advanced or metastatic urothelial carcinoma, according to findings from the phase 3 KEYNOTE-361 trial.

Pembrolizumab Combo Falls Short in Phase 3 Frontline Urothelial Carcinoma Trial

June 10th 2020

Adding pembrolizumab to chemotherapy did not lead to a statistically significant improvement in overall survival or progression-free survival in patients with advanced or metastatic urothelial carcinoma, according to findings from the phase 3 KEYNOTE-361 trial.

FDA Grants Margetuximab Orphan Drug Status for Gastric Cancer

June 5th 2020

The FDA has granted margetuximab an Orphan Drug designation for the treatment of patients with gastric and gastroesophageal junction cancer.

FDA Accepts Application for Ropeginterferon Alfa-2b for Polycythemia Vera

June 5th 2020

The FDA has accepted an application for ropeginterferon alfa-2b for use as a treatment for patients with polycythemia vera.

Subcutaneous Daratumumab Approved in Europe for Myeloma

June 4th 2020

The European Commission has approved subcutaneous formulation of daratumumab for the treatment of patients with multiple myeloma.

Isatuximab Approved in Europe for Relapsed/Refractory Myeloma

June 2nd 2020

The European Commission has approved isatuximab in combination with pomalidomide and dexamethasone for the treatment of adult patients with relapsed/refractory multiple myeloma who have received ≥2 prior therapies.

Melflufen Continues Advance Through Myeloma Pipeline

June 2nd 2020

An update on the phase 3 OCEAN study of melflufen in relapsed/refractory multiple myeloma reported that patients stayed on treatment longer than had been previously estimated.

Olaparib Approaches EU Approval for Frontline Maintenance in Pancreatic Cancer

June 1st 2020

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended olaparib for the maintenance treatment of adult patients with germline BRCA-mutated metastatic pancreatic adenocarcinoma.

Palbociclib Falls Short in Phase 3 Early Breast Cancer Trial

June 1st 2020

The phase 3 PALLAS trial exploring palbociclib (Ibrance) in patients with HR-positive, HER2-negative early breast cancer is unlikely to demonstrate a statistically significant improvement in the study’s primary end point of invasive disease-free survival.

EU Panel Backs Entrectinib for NTRK+ Tumors and ROS1+ NSCLC

June 1st 2020

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended entrectinib for the treatment of adult and pediatric patients ≥12 years of age with solid tumors that harbor an NTRK fusion, as well as for the treatment of adult patients with ROS1-positive, advanced non–small cell lung cancer not previously treated with ROS1 inhibitors.

Alpelisib Nears EU Approval for PIK3CA+ Breast Cancer

June 1st 2020

The European Medicines Agency’s Committee for Medicinal Products for Human Use has recommended the PI3K inhibitor alpelisib for use in combination with fulvestrant as treatment for patients with breast cancer.

Cabozantinib Plus Atezolizumab Shows Promise in mCRPC

May 31st 2020

The combination of cabozantinib and atezolizumab showed clinically meaningful activity in patients with metastatic castration-resistant prostate cancer.

Tislelizumab Frontline Combos Extend PFS in Squamous NSCLC

May 31st 2020

Combining the anti–PD-1 agent tislelizumab with chemotherapy improved progression-free survival compared with chemotherapy alone as a frontline treatment in Chinese patients with advanced squamous non–small cell lung cancer.

Update Sustains OS Benefit With Encorafenib/Cetuximab Regimens in BRAF+ mCRC

May 30th 2020

The latest results from the phase 3 BEACON CRC study continued to show an overall survival benefit for encorafenib plus cetuximab with or without binimetinib compared with cetuximab plus irinotecan-containing regimens in patients with BRAF V600E–mutated metastatic colorectal cancer.