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Avelumab/Axitinib Combo Approved in Europe for Frontline RCC

OncLive Staff
Published: Monday, Oct 28, 2019

James Larkin, MD, PhD

James Larkin, MD, PhD

The European Commission (EC) has approved the combination of avelumab (Bavencio) and axitinib (Inlyta) for the frontline treatment of adult patients with advanced renal cell carcinoma (RCC), EMD Serono (Merck KGaA) and Pfizer, the codevelopers of avelumab, reported in a press release.1

In May 2019, the FDA approved the combination of avelumab and axitinib in the frontline setting for patients with advanced renal cell carcinoma, also based on the JAVELIN Renal 101 data.


  1. European Commission Approves BAVENCIO® (avelumab) Plus Axitinib Combination for First-Line Treatment of Patients With Advanced Renal Cell Carcinoma. Posted October 28, 2019. Accessed October 27, 2018.
  2. Motzer RJ, Penkov K, Hannen JBAG, et al. JAVELIN Renal 101: a randomized, phase III study of avelumab + axitinib vs sunitinib as first-line treatment of advanced renal cell carcinoma (aRCC). In: Proceedings from the 2018 ESMO Congress; October 19-23, 2018; Munich, Germany. Abstract LBA6_PR.

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