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CAR T Cell Functionality Correlates With Outcomes, Offering a Biomarker for Response

Silas Inman @silasinman
Published: Tuesday, Apr 04, 2017

The flexibility of CAR T cells to perform multiple functions was associated with the level of clinical activity elicited for patients with advanced non-Hodgkin’s lymphoma (NHL), according to a retrospective analysis presented at the 2017 AACR Annual Meeting.

“Through this research, we were able to highlight the important role a functionally versatile subpopulation of CAR T cells may play in the fight against cancer, leading to new ways to characterize and optimize T-cell products," Adrian Bot, MD, Kite’s vice president, Translational Medicine, said in a statement. "These insights were made possible by using the IsoPlexis technology.”
Rossi J, Paczkowski P, Shen Y-W, et al. Polyfunctional anti-CD19 CAR T cells determined by single-cell multiplex proteomics associated with clinical activity in patients with advanced non-Hodgkin’s lymphoma. Presented at: 2017 AACR Annual Meeting; April 1-5, 2017; Washington, DC. Abstract 2990.

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