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Dabrafenib/Trametinib Combo Nears 70% Response in Thyroid Cancer

Jason Harris
Published: Thursday, Jan 04, 2018

Vivek Subbiah, MD
Vivek Subbiah, MD
Nearly 7 in 10 patients with locally advanced or metastatic BRAF V600E–mutated anaplastic thyroid cancer (ATC) responded to treatment with the combination of the BRAF inhibitor dabrafenib (Tafinlar) and the MEK inhibitor trametinib (Mekinist).

The most common AEs of any grade in the ATC cohort were fatigue (44%), pyrexia (31%), and nausea (31%). The most common grade 3/4 AE was anemia (13%). Three patients with ATC experienced treatment-related serious AEs.
Subbiah V, Kreitman RJ, Wainberg AZ, et al. Dabrafenib and Trametinib treatment in patients with locally advanced or metastatic BRAF V600–mutant anaplastic thyroid cancer. J Clin Oncol [published online ahead of print October 26, 2017] doi: 10.1200/JCO.2017.73.6785.

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Medical Crossfire®: How Can We Optimize Outcomes in Head and Neck Cancers with Immunotherapeutic Strategies?Oct 31, 20191.5
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