Charles Drake, MD, PhD
Sunitinib (Sutent) alone was noninferior for median overall survival (OS) compared with sunitinib plus cytoreductive nephrectomy in patients with synchronous metastatic renal cell carcinoma (mRCC), according to findings from the phase III noninferiority CARMENA trial presented at the 2018 ASCO Annual Meeting.
Charles G. Drake, MD, PhD, director of Genitourinary Oncology at New York-Presbyterian/Columbia University Medical Center and co-director of Columbia’s Cancer Immunotherapy Programs, discussed the importance of the CARMENA results, the future of cytoreductive nephrectomy, and how the use of immunotherapy could change treatment in this setting.
OncLive: What was the rationale for the study?
We really don't know, when a patient presents with metastatic kidney cancer, whether taking out the primary kidney lesion will help them live longer or better. There are a number of retrospective studies, but all of them are subject to bias because the surgeon picks the person who is healthy enough to have their kidney removed.
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