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Durvalumab Combo Misses OS Endpoint in Frontline Metastatic NSCLC

Jason M. Broderick
Published: Friday, Nov 16, 2018

Sean Bohen, MD, PhD

Sean Bohen, MD, PhD
The frontline combination of durvalumab (Imfinzi) and tremelimumab did not induce a statistically significant improvement in overall survival (OS) compared to standard chemotherapy in patients with metastatic (stage IV) non–small cell lung cancer (NSCLC).

Ongoing phase III trials of frontline durvalumab in stage IV NSCLC include PEARL (single-agent durvalumab vs standard chemotherapy), NEPTUNE (durvalumab/tremelimumab vs standard chemotherapy), and POSEIDON (durvalumab/chemotherapy or durvalumab/tremelimumab/chemotherapy versus standard chemotherapy).

References

  1. Antonia SJ, Villegas A, Daniel D, et al. Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer. N Engl J Med. 2017;377(20):1919-1929 doi: 10.1056/NEJMoa1709937.
  2. Antonia S, Villegas A, Daniel D, et al. Overall survival with durvalumab versus placebo after chemoradiotherapy in stage III NSCLC: updated results from PACIFIC. Presented at: the IASLC 19th World Conference on Lung Cancer; September 23-26, 2018; Toronto, Canada. Abstract PL02.01.
  3. Antonia S, Villegas A, Daniel D, et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC [published online ahead of print September 25, 2018]. N Eng J Med. doi: 10.1056/NEJMoa1809697.

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