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ECHELON-1 Analysis Shows Brentuximab Vedotin Activity in Nonpediatric AYA Hodgkin Lymphoma

Published: Wednesday, Dec 12, 2018

Howland E. Crosswell, MD

Howland E. Crosswell, MD

Nonpediatric young adults with stage III/IV Hodgkin lymphoma had significantly better progression-free survival (PFS) when treated with brentuximab vedotin (Adcetris) and conventional chemotherapy compared with standard therapy, according to a subgroup analysis of the ECHELON-1 trial that was presented at the 2018 ASH Annual Meeting.1

“Consistent with the overall trial results, this exploratory analysis demonstrated that adolescents and young adults receiving A+AVD had significantly improved modified PFS with manageable tolerability profile as compared with AYA patients receiving ABVD,” the investigators concluded. “A+AVD can be considered a treatment option for nonpediatric adolescents and young adult patients with advanced-stage classical Hodgkin lymphoma.

References

  1. Crosswell HE, LaCasce AS, Bartlett NL, et al. Brentuximab vedotin with chemotherapy in adolescents and young adults (AYA) with stage III or IV Hodgkin lymphoma: a subgroup analysis from the phase 3 ECHELON-1 study. In: Proceedings from the 2018 ASH Annual Meeting; December 1-4, 2018; San Diego, California. Abstract 1647.
  2. Connors J, Jurczak W, Straus D J., et al. Brentuximab vedotin plus doxorubicin, vinblastine, dacarbazine (A+AVD) as frontline therapy demonstrates superior modified progression-free survival versus ABVD in patients with previously untreated stage III or IV Hodgkin lymphoma (HL): the phase 3 echelon-1 study. Presented at: ASH Annual Meeting and Exposition; December 9-12, 2017; Atlanta. Abstract 6.

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