Howland E. Crosswell, MD
Nonpediatric young adults with stage III/IV Hodgkin lymphoma had significantly better progression-free survival (PFS) when treated with brentuximab vedotin (Adcetris) and conventional chemotherapy compared with standard therapy, according to a subgroup analysis of the ECHELON-1 trial that was presented at the 2018 ASH Annual Meeting.1
“Consistent with the overall trial results, this exploratory analysis demonstrated that adolescents and young adults receiving A+AVD had significantly improved modified PFS with manageable tolerability profile as compared with AYA patients receiving ABVD,” the investigators concluded. “A+AVD can be considered a treatment option for nonpediatric adolescents and young adult patients with advanced-stage classical Hodgkin lymphoma.
- Crosswell HE, LaCasce AS, Bartlett NL, et al. Brentuximab vedotin with chemotherapy in adolescents and young adults (AYA) with stage III or IV Hodgkin lymphoma: a subgroup analysis from the phase 3 ECHELON-1 study. In: Proceedings from the 2018 ASH Annual Meeting; December 1-4, 2018; San Diego, California. Abstract 1647.
- Connors J, Jurczak W, Straus D J., et al. Brentuximab vedotin plus doxorubicin, vinblastine, dacarbazine (A+AVD) as frontline therapy demonstrates superior modified progression-free survival versus ABVD in patients with previously untreated stage III or IV Hodgkin lymphoma (HL): the phase 3 echelon-1 study. Presented at: ASH Annual Meeting and Exposition; December 9-12, 2017; Atlanta. Abstract 6.
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