News >

ECHELON-1 Analysis Shows Brentuximab Vedotin Activity in Nonpediatric AYA Hodgkin Lymphoma

Published: Wednesday, Dec 12, 2018

Howland E. Crosswell, MD

Howland E. Crosswell, MD

Nonpediatric young adults with stage III/IV Hodgkin lymphoma had significantly better progression-free survival (PFS) when treated with brentuximab vedotin (Adcetris) and conventional chemotherapy compared with standard therapy, according to a subgroup analysis of the ECHELON-1 trial that was presented at the 2018 ASH Annual Meeting.1

“Consistent with the overall trial results, this exploratory analysis demonstrated that adolescents and young adults receiving A+AVD had significantly improved modified PFS with manageable tolerability profile as compared with AYA patients receiving ABVD,” the investigators concluded. “A+AVD can be considered a treatment option for nonpediatric adolescents and young adult patients with advanced-stage classical Hodgkin lymphoma.


  1. Crosswell HE, LaCasce AS, Bartlett NL, et al. Brentuximab vedotin with chemotherapy in adolescents and young adults (AYA) with stage III or IV Hodgkin lymphoma: a subgroup analysis from the phase 3 ECHELON-1 study. In: Proceedings from the 2018 ASH Annual Meeting; December 1-4, 2018; San Diego, California. Abstract 1647.
  2. Connors J, Jurczak W, Straus D J., et al. Brentuximab vedotin plus doxorubicin, vinblastine, dacarbazine (A+AVD) as frontline therapy demonstrates superior modified progression-free survival versus ABVD in patients with previously untreated stage III or IV Hodgkin lymphoma (HL): the phase 3 echelon-1 study. Presented at: ASH Annual Meeting and Exposition; December 9-12, 2017; Atlanta. Abstract 6.

... to read the full story
To Read the Full Story

View Conference Coverage
Online CME Activities
TitleExpiration DateCME Credits
Advances in™ Multiple Myeloma: Changing Treatment Paradigms and the Emerging Potential of CAR T-Cell TherapyAug 30, 20191.5
2nd Annual Live Medical Crossfire®: Hematologic Malignancies OnlineSep 28, 20198.0
Publication Bottom Border
Border Publication