Benjamin L. Maughan, MD, PharmD
Combining radium-223 dichloride (Xofigo) with enzalutamide (Xtandi) is safe and feasible for patients with metastatic castration-resistant prostate cancer (mCRPC), according to data presented at the 2018 ASCO Annual Meeting.
, Maughan, an instructor in the Division of Medical Oncology at Huntsman Cancer Institute, discussed the tolerability of combining radium-223 and enzalutamide, as well as the next steps with this combination.
OncLive: Please provide some background on the radium-223 and enzalutamide combination.
: With mCRPC—and more broadly speaking with prostate cancer in general—there's a growing trend toward doing more intense combination therapy…A combination that's been attractive [in mCRPC] is one of novel hormonal therapy, either abiraterone acetate (Zytiga) or enzalutamide, in combination with radium-223. All 3 of these agents are known to improve overall survival. They also have nonoverlapping toxicities. Therefore, the combinatory approach is certainly one potentially attractive way to improve outcomes.
More importantly, the question of the day is what the potential risk of this combination is in terms of SREs. In our study, there was no significant increase in these events, which were defined by fractures, symptomatic bone pain, etc. We also didn't see any fractures in our study, either with the combination or the enzalutamide arm. We certainly need more follow-up to be able to more convincingly say that these data are encouraging.
How long was the follow-up with these data?
The follow-up at the time of the ASCO deadline cutoff is slightly less than 1 year. The follow-up needs to go out further, so we can convincingly say that this combination does not increase the risk of fractures. However, the fact that we have seen no fractures to date is highly encouraging.
What do you expect to see with this combination in terms of efficacy?
This is the second most important question. It's obviously critical for us to see whether this combination is effective along with being safe. We will be able to answer this pretty well since it's a randomized study. At the time of the ASCO deadline, the primary efficacy results were not yet mature, but it has subsequently matured. Therefore, we are hoping to present these at upcoming meetings. There is more to come.
Why is there a trend of more intense combination therapies, as you mentioned?
This started with the CHAARTED trial, which looked at androgen deprivation therapy upfront. Since then, we have consistently seen more studies following the same direction. There are a lot of trials ongoing; for example, some are looking at chemotherapy plus hormonal therapy and abiraterone for metastatic hormone-sensitive disease. Triplet combinations in place of dual combinations are starting to emerge. In mCRPC, there are studies looking at abiraterone plus enzalutamide or radium-223 plus enzalutamide, and multiple other combinations.
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