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Expert Addresses Advances and Challenges in Bladder Cancer

Angelica Welch
Published: Wednesday, Mar 07, 2018

Mark Tyson, MD

Mark Tyson, MD
Developments in perioperative, systemic, and immune therapies have enriched the localized bladder cancer landscape. And with more options for management, urologists must learn how to integrate these therapies, yet also know when to ask for help from medical oncologists, says Mark Tyson, MD.

In an interview during the meeting, Tyson, a urologic oncologist at Mayo Clinic, discussed the management of localized advanced bladder cancer, the promise of immunotherapy, and his advice for urologists treating patients with bladder cancer.

OncLive: Please provide an overview of your presentation.

Tyson: There are a lot of exciting developments in the muscle-invasive bladder (MIBC) cancer space in the last few years. We have been giving neoadjuvant chemotherapy for a while now. One of the 2 trials I reviewed in the talk was the Medical Research Council trial that showed the benefit for 3 cycles of cisplatin, methotrexate, and vinblastine (CMV) in the neoadjuvant setting for patients receiving radiation plus surgery. There were some issues with that trial that led some to believe that the data might not be that compelling. For example, most people suggest that there should have been a benefit of 10% for it to be clinically meaningful, and at 8 years, the trial is deemed significant at 6%. 
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