Dustin M. Walters, MD
The heterogeneity of stage III NSCLC means there is not a one-size-fits-all strategy for patients. Rather, a multidisciplinary approach is required to optimally utilize the available tools of chemoradiation, immunotherapy, and surgery.
“We’ll have to figure out how to leverage all the benefits of all those therapies and time them appropriately [versus] a magic bullet or monotherapy that works well for these [patients],” said Dustin M. Walters, MD.
Exciting new data continue to expand the treatment options available for these multidisciplinary strategies. For example, following the readout of the PACIFIC trial, the use of durvalumab (Imfinzi) after chemoradiotherapy became a standard option in the treatment paradigm for patients with unresectable stage III NSCLC. Results of the study demonstrated an 11.2-month improvement in progression-free survival (PFS) with durvalumab versus placebo (16.8 vs 5.6; HR, 0.52; 95% CI, 0.42-0.65; P
<.0001). The 18-month PFS rate was 44.2% compared with 27.0% in favor of the durvalumab arm.
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