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Expert Highlights Potential of Moxetumomab Pasudotox in Hairy Cell Leukemia

Brandon Scalea
Published: Tuesday, Jul 17, 2018

Robert J. Kreitman, MD

Robert J. Kreitman, MD
Moxetumomab pasudotox, a recombinant immunotoxin that targets CD22, demonstrated significant clinical activity in patients with relapsed/refractory hairy cell leukemia, according to findings from an international phase III trial presented at the 2018 ASCO Annual Meeting.

Hairy cell leukemia is a rare B-cell malignancy distinguished by high CD22 expression. When moxetumomab, fused with a p38 toxin, binds to CD22 and internalizes, it inhibits protein synthesis and leads to cell death, explained lead author, Robert J. Kreitman, MD.
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