Michael A. Morse, MD
At the 2018 Gastrointestinal (GI) Cancers Symposium, results from the phase II REVERCE study revealed the superiority of sequencing regorafenib (Stivarga) before cetuximab (Erbitux) to the reverse sequence in patients with metastatic colorectal cancer (mCRC) who progressed on standard chemotherapy.
on Gastrointestinal Cancers, Michael A. Morse, MD, professor of medicine, Department of Surgery, Duke University School of Medicine, Duke Cancer Institute, discussed a number of key trials that have broadened the treatment landscape of mCRC, the importance of toxicity management in this setting, and other ongoing developments in GI cancers.
OncLive: What is the current state of treatment in mCRC?
The developments at the 2018 GI Symposium in advanced colon cancer, specifically patients who have progressed on standard third-line therapies and beyond, focused on several areas. There was an interesting study that questioned the preferred order of regorafenib and then cetuximab in patients. Patients were randomized to receive regorafenib first, followed by cetuximab at progression, or cetuximab followed by regorafenib at progression. Surprisingly, there was an OS benefit for the sequence where patients received regorafenib first followed by cetuximab. This was mainly in the group of patients who had primary left-sided tumors and were wild-type for KRAS, NRAS,
Please expand on sequencing agents in this setting.
Patients with colon cancer, particularly if they have RAS
wild-type tumors, essentially have 5 lines of therapy. It’s important that people receive all of the lines of therapy to have the best chance of survival. In frontline treatments, people have a choice of different chemotherapy drugs, depending on what toxicities they’re concerned about. They have a choice of biologic agents, assuming they’re RAS
wild-type and have a left-sided tumor. We have effective second-line therapies, predominantly using what wasn't used in the first-line setting. We also have oral agents for later lines of therapy.
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