David C. Portnoy, MD
Ongoing clinical trials are investigating targeted agents for KRAS, MET,
mutations in non–small cell lung cancer (NSCLC). As more mutations are identified, the treatment landscape continues to shift away from chemotherapy regimens and toward biomarker-driven approaches, some of which include targeted agents plus immunotherapies, explains David C. Portnoy, MD.
on Advanced Non–Small Cell Lung Cancer, Portnoy, a hematologist and medical oncologist at West Cancer Center, assistant professor of medicine at Nova Southeastern College of Osteopathic Medicine, the University of Tennessee Health Science Center, discussed emerging developments with targeted agents in lung cancer.
OncLive: How has the identification of ALK, EGFR, and other molecular markers helped drive treatment in NSCLC?
In the past, all NSCLCs were treated exactly the same. Histology didn't matter and molecular underpinnings with a cancer didn't matter; they all were treated with chemotherapy whether you had squamous cell disease or adenocarcinoma. Everyone knows how chemotherapy makes patients feel, and of course there are the toxicities and limitations of chemotherapy. With chemotherapy alone, life expectancy for some metastatic NSCLCs is generally under 1 year.
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