Pierre Massion, MD
Preliminary results of the National Lung Screening Trial in 2011 revealed that patients with lung cancer who received low-dose CT scans had a 15% to 20% lower risk of death from their disease versus those who had standard chest X-rays—a significant finding in the field that led to screening guidelines for clinical practice in the United States.
In an interview during the meeting, Massion spoke to the necessity of having more people undergo lung cancer screening, ongoing clinical trials emphasizing the importance of early detection, and how to determine who is at highest risk for lung cancer.
OncLive: Please provide an overview of your lecture on screening.
I focused on early detection because it [has been] a revolution in the field since 2011. We have heard the results of the National Lung Screening Trial, and these results are important and have led to a series of changes in guidelines that promote lung cancer screening in the high-risk population.
There is a lot of room for a better understanding of the biology of the disease, understanding how people are at higher risk and what that means, and how we can get biology to correlate for this risk assessment. This is a big area of research of interest of mine.
What types of clinical trials are being done now to answer these questions?
There are multiple trials ongoing in screening in particular, not only in the United States but in Canada, the Netherlands, and Belgium. The NELSON trial is a similar trial to the National Lung Screening Trial. It randomizes people between lung cancer CT screening with a standard of care, which is no screening, among 20,000 people or a little fewer. The results of this trial should likely be publicized next year. We are eagerly awaiting the results because [they] will have big implications for implementation of the screening approach in Europe.
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