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FDA Approves Durvalumab for Locally Advanced NSCLC

Jason M. Broderick @jasoncology
Published: Friday, Feb 16, 2018

Richard Pazdur, MD
Richard Pazdur, MD
The FDA has approved durvalumab (Imfinzi) for the treatment of patients with locally advanced, unresectable stage III non–small cell lung cancer (NSCLC) who have not progressed following chemoradiotherapy.

"Until now, treatment guidelines have recommended that patients with unresectable stage III lung cancer undergo a period of active surveillance following chemoradiation therapy until disease progression. Given that up to 89% of patients will progress to metastatic disease, it is important that there is now a new option that can give patients more time without disease progression. The PACIFIC trial data supporting today's approval of Imfinzi will change how we treat these patients," PACIFIC trial investigator Scott J. Antonia, MD, PhD, chair of the Thoracic Oncology Department at the H. Lee Moffitt Cancer Center and Research Institute, said in a statement.
Antonia SJ, Villegas A, Daniel D, et al. Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer. N Engl J Med. 2017;377(20):1919-1929 doi: 10.1056/NEJMoa1709937.

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