The FDA has approved the combination of avelumab (Bavencio) and axitinib (Inlyta) for the frontline treatment of patients with advanced renal cell carcinoma.1
Moreover, the European Medicines Agency validated a Type II variation application for the combination of avelumab and axitinib in advanced RCC in March 2019. A supplemental application for the combination for patients with unresectable or metastatic RCC was submitted in Japan in January 2019.
- FDA Approves Bavencio (Avelumab) Plus Inlyta (Axitinib) Combination for Patients With Advanced Renal Cell Carcinoma. Pfizer Oncology. Published May 14, 2019. https://on.pfizer.com/2HtdCzF. Accessed May 14, 2019.
- Motzer RJ, Penkov K, Hannen JBAG, et al. JAVELIN Renal 101: a randomized, phase III study of avelumab + axitinib vs sunitinib as first-line treatment of advanced renal cell carcinoma (aRCC). In: Proceedings from the 2018 ESMO Congress; October 19-23, 2018; Munich, Germany. Abstract LBA6_PR.
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