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Frontline Nivolumab/Ipilimumab Improves PFS in High TMB NSCLC

Jason Harris
Published: Monday, Feb 05, 2018

Matthew D. Hellmann, MD

Matthew D. Hellmann, MD
The combination of nivolumab (Opdivo) and ipilimumab (Yervoy) improved progression-free survival (PFS) compared with chemotherapy in treatment-naïve patients with high tumor mutation burden (TMB) non–small cell lung cancer (NSCLC).

When efficacy was compared between monotherapy and each of the combination arms in patients with PD-L1 expression ≥1%, median PFS was greatest in the nivolumab every 2 weeks, ipilimumab every 6 weeks interval cohort. Median PFS in this setting was 3.5 versus 10.4 versus 13.2 weeks, in patients receiving monotherapy, ipilimumab every 12 weeks, and ipilimumab every 6 weeks, respectively. Median 1-year OS rates showed a similar pattern; median OS was 69% with monotherapy, 91% with combined ipilimumab given every 6 weeks, and 83% with combined ipilimumab given every 12 weeks.
1. First-line nivolumab monotherapy and nivolumab plus ipilimumab in patients with advanced NSCLC: long-term outcomes from CheckMate-012. Presented at: International Association for the Study of Lung Cancer 17th World Conference on Lung Cancer (WCLC) in Vienna, Austria.

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