Sean Bohen, MD, PhD
Frontline osimertinib (Tagrisso) significantly improved progression-free survival (PFS) versus standard of care in patients with locally-advanced or metastatic EGFR
-positive non–small cell lung cancer (NSCLC), according to results from the phase III FLAURA trial.
Grade ≥3 AEs were reported in 23% of the osimertinib group versus 47% of the chemotherapy arm. The most frequently reported grade ≥3 events in the chemotherapy arm were neutropenia (12%), anemia (12%), and thrombocytopenia (7%). The incidence of each of those toxicities in the osimertinib arm was 1% or less.
- Ramalingam S, Yang JC, Lee CK, et al. Osimertinib as first-line treatment for EGFR mutation-positive advanced NSCLC: updated efficacy and safety results from two phase I expansion cohorts. Presented at: 2016 European Lung Cancer Conference; April 13-16, 2016; Geneva, Switzerland. Abstract LBA 1.
- Mok TS, Wu YL, Ahn MJ, et al. The AURA3 Investigators. Osimertinib or platinum–pemetrexed in EGFR T790M–positive lung cancer. N Engl J Med. 2017; 376:629-640.
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